Endocrine Abstracts

Type 2 diabetes (T2D) affects 1 in 15 people in the U.K, ischaemic damage is predominant and caused by hypoxia. The physiological response to hypoxia is an increase in the transcription factor hypoxia inducible factor (HIF)-1α, which results in reduced oxygen consuming. Previously we have demonstrated that the diabetic heart fails to respond to hypoxia and the aim of this work was to determine if a similar effect was seen in the kidney. HEK293T cells were incubated for 8h...

Increased fatty acid (FA) concentration is implicated in the development of insulin resistance (IR) in tissues such as the kidney. Research indicates the protective role of glucagon-like peptide (GLP)-1 receptor agonists; GLP-1 (7-36) amide and incretin mimetic; liraglutide, against IR. We aimed to induce IR in HEK293T cells, using the three most abundantly consumed FAs; palmitate, oleate, and stearate, or in a combination termed POS. This model was used to assess the extent o...